Tg(Gnrh1-cre)1Rsp
Transgene Detail
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Symbol: |
Tg(Gnrh1-cre)1Rsp |
Name: |
transgene insertion 1, Rolf Sprengel |
MGI ID: |
MGI:3612443 |
Synonyms: |
TgGnRH-iCre |
Transgene: |
Tg(Gnrh1-cre)1Rsp Location: unknown
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Alliance: |
Tg(Gnrh1-cre)1Rsp page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Gnrh1-cre)1Rsp expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Gnrh1 (MGI:95789) |
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Mutation details: The mouse gonadotropin-releasing hormone promoter was used to drive the expression of improved cre (icre). The icre was assembled from oligonucleotides to introduce silent base mutations corresponding to human codon-usage preferences, minimize CpG content, eliminate putative cryptic splice sites and alter the stop codon. Cre activity was detected in 97% of Gnrh immunopositive neurons and in a second population of cells, mainly the limbic system neurons. Four lines exhibiting high expression and three with low expression were obtained. This is a representative from those lines.
(J:78663)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Gnrh1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:78663 Shimshek DR, et al., Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis. 2002 Jan;32(1):19-26 |
All: |
2 reference(s) |
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