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Targeted Allele Detail
Symbol: Pkd1tm1Ggg
Name: polycystic kidney disease 1 homolog; targeted mutation 1, Gregory G Germino
MGI ID: MGI:3612339
Synonyms: Pkd1-, Pkd1Beta-gal null, Pkd1Betagal-null
Gene: Pkd1  Location: Chr17:24549950-24596514 bp, + strand  Genetic Position: Chr17, 12.4 cM
Osteopenia in newborn Pkd1tm1Ggg/Pkd1tm2Ggg Tg(Col1a1-cre)1Bek/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:76062
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 2 and all of exon 3 were replaced with lacZ gene in frame to the 5' end of exon 2. This is a true null allele because of transcription termination after the beta-galactosidase gene. lacZ expression is driven by the endogenous promoter. (J:76062, J:103719)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  8 strains or lines available
Original:  J:76062 Bhunia AK, et al., PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell. 2002 Apr 19;109(2):157-68
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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