About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Fscn2tm1Sykk
Name: fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus); targeted mutation 1, Shunji Yokokura
MGI ID: MGI:3612337
Synonyms: Fscn2p neo(-)
Gene: Fscn2  Location: Chr11:120361534-120368168 bp, + strand  Genetic Position: Chr11, 84.08 cM
Germline Transmission:  Earliest citation of germline transmission: J:103713
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA fragment lacking a guanine at nucleotide 208 of the gene replaced the endogenous sequence by homologous recombination. Cre mediated recombination removed a floxed neomycin selection cassette. RT-PCR did not detect transcript using primers designed to amplify sequence downstream of the deleted guanine. (J:103713)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fscn2 Mutation:  7 strains or lines available
Original:  J:103713 Yokokura S, et al., Targeted disruption of FSCN2 gene induces retinopathy in mice. Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2905-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory