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Smc1atm1Mbk
Targeted Allele Detail
Nomenclature
Symbol: Smc1atm1Mbk
Name: structural maintenance of chromosomes 1A; targeted mutation 1, Michael B Kastan
MGI ID: MGI:3612278
Synonyms: Smc1S957AS966A
Gene: Smc1a  Location: ChrX:150799386-150844969 bp, + strand  Genetic Position: ChrX, 68.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104490
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
    Two serines were mutated to alanines at positions 957 and 966 in exon 19. (J:104490)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smc1a Mutation:  9 strains or lines available
References
Original:  J:104490 Kitagawa R, et al., Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004 Jun 15;18(12):1423-38
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory