Gria3^tm1Rsp
Targeted Allele Detail

Summary

• Symbol: Gria3^tm1Rsp
• Name: glutamate receptor, ionotropic, AMPA3 (alpha 3); targeted mutation 1, Rolf Sprengel
• MGI ID: MGI:3611328
• Synonyms: GluR-C^3lox
• Gene: Gria3 Location: ChrX:40489731-40767478 bp, + strand Genetic Position: ChrX, 23.19 cM
• Alliance: Gria3^tm1Rsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104146
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed PGK-neo selection cassette was inserted in intron 11 and a third loxP element was inserted 900bp upstream of exon 11. Exon 11 encodes the essential channel pore regions M1 and M2. Four silent mutations were introduced into exon 11 as well. (J:104146)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gria3 Mutation: 10 strains or lines available

References

• Original: J:104146 Sanchis-Segura C, et al., Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. J Neurosci. 2006 Jan 25;26(4):1231-8
• All: 22 reference(s)