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Gt(ROSA)26Sortm1(DTA)Jpmb
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(DTA)Jpmb
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Juan Pedro Martinez-Barbera
MGI ID: MGI:3610389
Synonyms: LSL-R26DTA, R26DTA, ROSA26eGFP-DTA, ROSA26GFP-DTA
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Cardiovascular abnormalities in Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+ Tg(Smad7-cre)1Sjc/0 embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103417
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Mutation detailsA targeting vector contained a conditionally expressed DTA construct downstream of a floxed DNA region containing EGFP, a neo cassette and a triple SV40. An EGFP is upstream of the DTA and is constitutively expressed under the control of the ROSA26 protmoter. (J:103417)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 17 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  765 strains or lines available
Notes
The time lapse between onset of Cre expression and cell death is estimated to be less than 24 hours.
References
Original:  J:103417 Ivanova A, et al., In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis. 2005 Nov;43(3):129-35
All:  95 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory