Gt(ROSA)26Sor^tm1(DTA)Jpmb
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(DTA)Jpmb
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Juan Pedro Martinez-Barbera
• MGI ID: MGI:3610389
• Synonyms: LSL-R26^DTA, R26^DTA, ROSA26^eGFP-DTA, ROSA26GFP-DTA
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(DTA)Jpmb page

Cardiovascular abnormalities in Gt(ROSA)26Sor^tm1(DTA)Jpmb/Gt(ROSA)26Sor⁺ Tg(Smad7-cre)1Sjc/0 embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103417
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector contained a conditionally expressed DTA construct downstream of a floxed DNA region containing EGFP, a neo cassette and a triple SV40. An EGFP is upstream of the DTA and is constitutively expressed under the control of the ROSA26 protmoter. (J:103417)

Disease models

Expression

In Mice Carrying this Mutation:

17 assay results

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^tm1(DTA)Jpmb

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

Notes

The time lapse between onset of Cre expression and cell death is estimated to be less than 24 hours.

References

• Original: J:103417 Ivanova A, et al., In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis. 2005 Nov;43(3):129-35
• All: 109 reference(s)