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Tlr1tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Tlr1tm1Aki
Name: toll-like receptor 1; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3609369
Synonyms: Tlr1-
Gene: Tlr1  Location: Chr5:64924679-64933563 bp, - strand  Genetic Position: Chr5, 33.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:103395
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced a portion of an exon containing amino acids 575-795 of the locus, sequence encoding the transmembrane and cytoplasmic regions of the protein. Northern blot failed to detect transcript in mutants. (J:103395)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr1 Mutation:  26 strains or lines available
References
Original:  J:103395 Takeuchi O, et al., Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol. 2002 Jul 1;169(1):10-4
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory