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Cacng8tm1Ran
Targeted Allele Detail
Nomenclature
Symbol: Cacng8tm1Ran
Name: calcium channel, voltage-dependent, gamma subunit 8; targeted mutation 1, Roger A Nicoll
MGI ID: MGI:3609205
Synonyms: gamma-8-
Gene: Cacng8  Location: Chr7:3442558-3464782 bp, + strand  Genetic Position: Chr7, 1.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102515
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe locus was disrupted by the replacement of exons 2 and 3 with a neomycin resistance gene. Quantitative immunoblot of hippocampal extracts of mutants confirms the absence of protein. (J:102515)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cacng8 Mutation:  23 strains or lines available
References
Original:  J:102515 Rouach N, et al., TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Nat Neurosci. 2005 Nov;8(11):1525-33
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory