About   Help   FAQ
Apoc3tm1Lap
Targeted Allele Detail
Nomenclature
Symbol: Apoc3tm1Lap
Name: apolipoprotein C-III; targeted mutation 1, Len A Pennacchio
MGI ID: MGI:3609193
Gene: Apoc3  Location: Chr9:46232933-46235636 bp, - strand  Genetic Position: Chr9, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102319
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsES cells with a hygromycin resistance gene replacing the entire Apoa5 locus were targeted a second time with a vector designed to replace exon 4 of Apoc3 with a neomycin resistance gene. Northern blot revealed that the mutant mice lacked both Apoa5 and Apoc3 transcripts. (J:102319)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoc3 Mutation:  4 strains or lines available
References
Original:  J:102319 Baroukh N, et al., Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice. Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1297-302
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/21/2017
MGI 6.08
The Jackson Laboratory