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Apoc3tm1Lap
Targeted Allele Detail
Nomenclature
Symbol: Apoc3tm1Lap
Name: apolipoprotein C-III; targeted mutation 1, Len A Pennacchio
MGI ID: MGI:3609193
Gene: Apoc3  Location: Chr9:46232933-46235636 bp, - strand  Genetic Position: Chr9, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102319
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsES cells with a hygromycin resistance gene replacing the entire Apoa5 locus were targeted a second time with a vector designed to replace exon 4 of Apoc3 with a neomycin resistance gene. Northern blot revealed that the mutant mice lacked both Apoa5 and Apoc3 transcripts. (J:102319)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apoc3 Mutation:  3 strains or lines available
References
Original:  J:102319 Baroukh N, et al., Analysis of apolipoprotein A5, c3, and plasma triglyceride concentrations in genetically engineered mice. Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1297-302
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory