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Targeted Allele Detail
Symbol: Fancatm1Zqw
Name: Fanconi anemia, complementation group A; targeted mutation 1, Zhao-Qi Wang
MGI ID: MGI:3609190
Synonyms: Fancadelta
Gene: Fanca  Location: Chr8:123268300-123318576 bp, - strand  Genetic Position: Chr8, 72.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:102526
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA neomycin resistance gene flanked by loxP sites was inserted into intron 36 and a third loxP site was inserted into intron 39. Transient transfection with cre recombinase resulted in the loss of exons 37-39. Western blot failed to detect protein in ES cells and fibroblasts. (J:102526)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fanca Mutation:  6 strains or lines available
Original:  J:102526 Yang YG, et al., The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis. 2005 Oct;26(10):1731-40
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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