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Targeted Allele Detail
Symbol: Rhbgtm1Rc
Name: Rhesus blood group-associated B glycoprotein; targeted mutation 1, Regine Chambrey
MGI ID: MGI:3608962
Synonyms: RHbg-
Gene: Rhbg  Location: Chr3:88242874-88254709 bp, - strand  Genetic Position: Chr3, 38.78 cM
Germline Transmission:  Earliest citation of germline transmission: J:102456
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a copy of exons 2-5 with a 1.7 kb gap in the intronic region adjacent to exon 2, thereby creating an allele with duplicate exons. The vector also contained a puromycin resistance gene, 3' hprt and the K14Agouti transgene. No protein was detected in mutant mice either in the kidney or liver. (J:102456)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhbg Mutation:  11 strains or lines available
Original:  J:102456 Chambrey R, et al., Genetic ablation of Rhbg in the mouse does not impair renal ammonium excretion. Am J Physiol Renal Physiol. 2005 Dec;289(6):F1281-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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