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Itgb8tm2Lfr
Targeted Allele Detail
Nomenclature
Symbol: Itgb8tm2Lfr
Name: integrin beta 8; targeted mutation 2, Louis F Reichardt
MGI ID: MGI:3608910
Synonyms: Itgb8fl, itgbeta8flox
Gene: Itgb8  Location: Chr12:119162803-119238276 bp, - strand  Genetic Position: Chr12, 63.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102190
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA pgk-neo flanked by FRT sites with a loxP site at the 3' end was inserted into intron 4. A second loxP site was inserted into intron 3. Crossing with mice expressing FLP recombinase removed the pgk-neo, leaving mice with a flanked exon 4. Exon 4 encodes the integrin I-like domain. Cre-mediated deletion of this exon would result in a translational frameshift that generates a premature stop codon. (J:102190)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb8 Mutation:  1 strain or line available
References
Original:  J:102190 Proctor JM, et al., Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci. 2005 Oct 26;25(43):9940-8
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory