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Fut8tm1Nta
Targeted Allele Detail
Nomenclature
Symbol: Fut8tm1Nta
Name: fucosyltransferase 8; targeted mutation 1, Naoyuki Taniguchi
MGI ID: MGI:3608699
Synonyms: Fut8-
Gene: Fut8  Location: Chr12:77238125-77476338 bp, + strand  Genetic Position: Chr12, 35.46 cM
Growth retardation in Fut8tm1Nta/Fut8tm1Nta mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102932
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, which contains the translation initiation site, was replaced with an IRES-LacZ-Neo-pA cassette. Northern blot analysis of lung and brain RNA confirmed absence of full-length mRNA. (J:102932)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fut8 Mutation:  27 strains or lines available
References
Original:  J:102932 Wang X, et al., Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15791-6
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/03/2018
MGI 6.12
The Jackson Laboratory