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Eif4ebp2tm1Klan
Targeted Allele Detail
Nomenclature
Symbol: Eif4ebp2tm1Klan
Name: eukaryotic translation initiation factor 4E binding protein 2; targeted mutation 1, Eric Klann
MGI ID: MGI:3607258
Synonyms: 4E-BP2 KO
Gene: Eif4ebp2  Location: Chr10:61428491-61452661 bp, - strand  Genetic Position: Chr10, 32.21 cM, cytoband B4-B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102163
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 2, disrupting amino acids 49-110. Western blot of hippocampal, cortical and cerebellar extracts confirmed the absence of protein in mutants. (J:102163)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eif4ebp2 Mutation:  16 strains or lines available
References
Original:  J:102163 Banko JL, et al., The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. J Neurosci. 2005 Oct 19;25(42):9581-90
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory