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Nr0b2tm1Rus
Targeted Allele Detail
Nomenclature
Symbol: Nr0b2tm1Rus
Name: nuclear receptor subfamily 0, group B, member 2; targeted mutation 1, David W Russell
MGI ID: MGI:3607116
Synonyms: Shp-
Gene: Nr0b2  Location: Chr4:133553376-133556536 bp, + strand  Genetic Position: Chr4, 66.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:102129
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted into exon 1 to disrupt the locus, eliminating the required portions of the ligand binding and dimerization domains. Northern blot analysis of mutant liver failed to detect protein. (J:102129)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr0b2 Mutation:  7 strains or lines available
References
Original:  J:102129 Kerr TA, et al., Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev Cell. 2002 Jun;2(6):713-20
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory