Mybpc3^tm1Lcrr
Targeted Allele Detail

Summary

• Symbol: Mybpc3^tm1Lcrr
• Name: myosin binding protein C, cardiac; targeted mutation 1, Lucie Carrier
• MGI ID: MGI:3606208
• Synonyms: cMyBP-c^-
• Gene: Mybpc3 Location: Chr2:90948489-90966861 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Mybpc3^tm1Lcrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101903
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the transcription initiation site, all of exon 1 and most of exon 2, resulting in complete transcriptional inactivation. (J:101903)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybpc3 Mutation: 41 strains or lines available

References

• Original: J:101903 Carrier L, et al., Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res. 2004 Aug 1;63(2):293-304
• All: 19 reference(s)