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Mybpc3tm1Lcrr
Targeted Allele Detail
Nomenclature
Symbol: Mybpc3tm1Lcrr
Name: myosin binding protein C, cardiac; targeted mutation 1, Lucie Carrier
MGI ID: MGI:3606208
Synonyms: cMyBP-c-
Gene: Mybpc3  Location: Chr2:91118144-91136516 bp, + strand  Genetic Position: Chr2, 50.44 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101903
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced the transcription initiation site, all of exon 1 and most of exon 2, resulting in complete transcriptional inactivation. (J:101903)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mybpc3 Mutation:  21 strains or lines available
References
Original:  J:101903 Carrier L, et al., Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice. Cardiovasc Res. 2004 Aug 1;63(2):293-304
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory