Cox10^tm1Ctm
Targeted Allele Detail

Summary

• Symbol: Cox10^tm1Ctm
• Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10; targeted mutation 1, Carlos T Moraes
• MGI ID: MGI:3605782
• Synonyms: Cox10^f, COX10^Flx
• Gene: Cox10 Location: Chr11:63853453-63970294 bp, - strand Genetic Position: Chr11, 39.47 cM
• Alliance: Cox10^tm1Ctm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101747
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 6. This exon is homologous to sequence encoding part of the active site of the bacterial enzyme. (J:101747)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cox10 Mutation: 20 strains or lines available

References

• Original: J:101747 Diaz F, et al., Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum Mol Genet. 2005 Sep 15;14(18):2737-48
• All: 31 reference(s)