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Cox10tm1Ctm
Targeted Allele Detail
Nomenclature
Symbol: Cox10tm1Ctm
Name: heme A:farnesyltransferase cytochrome c oxidase assembly factor 10; targeted mutation 1, Carlos T Moraes
MGI ID: MGI:3605782
Synonyms: Cox10f, COX10Flx
Gene: Cox10  Location: Chr11:63853453-63970294 bp, - strand  Genetic Position: Chr11, 39.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101747
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exon 6. This exon is homologous to sequence encoding part of the active site of the bacterial enzyme. (J:101747)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cox10 Mutation:  12 strains or lines available
References
Original:  J:101747 Diaz F, et al., Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Hum Mol Genet. 2005 Sep 15;14(18):2737-48
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory