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Prdm1tm1Clme
Targeted Allele Detail
Nomenclature
Symbol: Prdm1tm1Clme
Name: PR domain containing 1, with ZNF domain; targeted mutation 1, Kathryn Calame
MGI ID: MGI:3605621
Synonyms: Blimp-1flox, Prdm1CA, Prdm1flox
Gene: Prdm1  Location: Chr10:44437177-44528501 bp, - strand  Genetic Position: Chr10, 23.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101890
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted to flank exons 6-8, encompassing sequence that encodes the zinc finger motifs. (J:101890)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prdm1 Mutation:  19 strains or lines available
References
Original:  J:101890 Shapiro-Shelef M, et al., Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity. 2003 Oct;19(4):607-20
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory