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Npas3tm1Ewb
Targeted Allele Detail
Nomenclature
Symbol: Npas3tm1Ewb
Name: neuronal PAS domain protein 3; targeted mutation 1, Eric W Brunskill
MGI ID: MGI:3605473
Synonyms: Npas3-
Gene: Npas3  Location: Chr12:53248677-54072175 bp, + strand  Genetic Position: Chr12, 22.31 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101561
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exon containing the basic helix-loop-helix domain was replaced with a neomycin resistance gene. Absence of transcript was confirmed by Northern blot of mutant brain samples. (J:101561)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npas3 Mutation:  21 strains or lines available
References
Original:  J:101561 Brunskill EW, et al., Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur J Neurosci. 2005 Sep;22(6):1265-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory