Npas3^tm1Ewb
Targeted Allele Detail

Summary

• Symbol: Npas3^tm1Ewb
• Name: neuronal PAS domain protein 3; targeted mutation 1, Eric W Brunskill
• MGI ID: MGI:3605473
• Synonyms: Npas3^-
• Gene: Npas3 Location: Chr12:53294940-54118958 bp, + strand Genetic Position: Chr12, 22.31 cM, cytoband C1
• Alliance: Npas3^tm1Ewb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101561
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon containing the basic helix-loop-helix domain was replaced with a neomycin resistance gene. Absence of transcript was confirmed by Northern blot of mutant brain samples. (J:101561)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npas3 Mutation: 41 strains or lines available

References

• Original: J:101561 Brunskill EW, et al., Abnormal neurodevelopment, neurosignaling and behaviour in Npas3-deficient mice. Eur J Neurosci. 2005 Sep;22(6):1265-76
• All: 1 reference(s)