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Gria1tm2Rlh
Targeted Allele Detail
Nomenclature
Symbol: Gria1tm2Rlh
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 2, Richard L Huganir
MGI ID: MGI:3605220
Synonyms: GluR1delta7
Gene: Gria1  Location: Chr11:56902342-57221070 bp, + strand  Genetic Position: Chr11, 34.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101578
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA mutation introduced a seven amino acid deletion in exon 17, thereby removing the PDZ ligand. Protein was detected in mutants when raised by an antibody against the last 80 amino acids of the C terminus, however, not when raised by an antibody against the last 20 amino acids. (J:101578)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:  44 strains or lines available
References
Original:  J:101578 Kim CH, et al., Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1. Nat Neurosci. 2005 Aug;8(8):985-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory