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Dusp9tm1Skey
Targeted Allele Detail
Nomenclature
Symbol: Dusp9tm1Skey
Name: dual specificity phosphatase 9; targeted mutation 1, Stephen M Keyse
MGI ID: MGI:3604672
Synonyms: DUSP9-
Gene: Dusp9  Location: ChrX:73639419-73643514 bp, + strand  Genetic Position: ChrX, 37.37 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101370
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with the En2A-IRESbetageoPA cassette. The replaced sequence encodes amino acids 194 to 452, encompassing the entire catalytic domain of the protein, including the protein tyrosine phosphatase active-site motif HCXXGXXRS. Western blot failed to detect protein in mutant ES cells. (J:101370)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 134 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dusp9 Mutation:  2 strains or lines available
References
Original:  J:101370 Christie GR, et al., The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Mol Cell Biol. 2005 Sep;25(18):8323-33
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory