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Tg(Plp1-SNCA)1Haa
Transgene Detail
Nomenclature
Symbol: Tg(Plp1-SNCA)1Haa
Name: transgene insertion 1, Christian Haass
MGI ID: MGI:3604008
Transgene: Tg(Plp1-SNCA)1Haa  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe proteolipid protein promoter was used to drive human wild-type alpha synuclein expression. Transgenic protein was detected in oligodendrocytes but in no other brain cell type. Lines 5, 25 and 27 were also created. (J:100960)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Multiple System Atrophy in hemizygous mice (J:96778)

References
Original:  J:100960 Kahle PJ, et al., Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep. 2002 Jun;3(6):583-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory