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Tg(Camk2a-MAPT*R406W)748Atak
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-MAPT*R406W)748Atak
Name: transgene insertion 748, Akihiko Takashima
MGI ID: MGI:3603948
Transgene: Tg(Camk2a-MAPT*R406W)748Atak  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Camk2a-MAPT*R406W)748Atak expresses 1 gene
 
Mutation detailsAn 8.5 kb portion of the calcium/calmodulin-dependent protein kinase II alpha promoter was used to drive the human microtubule-associated protein tau with the R406W mutation postnataly in forebrain neurons. Protein was expressed the greatest in the hippocampus, followed in decreasing amounts by the neocortex, the olfactory bulb, the striatum, and the thalamus. Mutant protein was barely detectable in the midbrain, the cerebellum and the spinal cord. Lines 502, 492 and 483 demonstrated similar expression patterns. (J:100958)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100958 Tatebayashi Y, et al., Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory