Tg(Eno2-APPSwe)1228Ykk
Transgene Detail

Summary

• Symbol: Tg(Eno2-APPSwe)1228Ykk
• Name: transgene insertion 1228, Yong K Kim
• MGI ID: MGI:3603945
• Synonyms: Am1228
• Transgene: Tg(Eno2-APPSwe)1228Ykk Location: unknown
• Alliance: Tg(Eno2-APPSwe)1228Ykk page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-APPSwe)1228Ykk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The neuron specific rat enolase 2 promoter was used to drive expression of the amyloid protein precursor bearing the Swedish mutation (K670N/M671L). In this line, the level of the 42-amino acid form of the protein was higher than in control mice. (J:100955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100955 Hwang DY, et al., Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw. Exp Neurol. 2004 Mar;186(1):20-32
• All: 1 reference(s)