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Targeted Allele Detail
Symbol: Lhx8tm1Vpa
Name: LIM homeobox protein 8; targeted mutation 1, Vassilis Pachnis
MGI ID: MGI:3603531
Synonyms: Lhx7nLacZ, Lhx8tm1Pach
Gene: Lhx8  Location: Chr3:154306294-154330659 bp, - strand  Genetic Position: Chr3, 79.12 cM, cytoband H3-H4
Germline Transmission:  Earliest citation of germline transmission: J:101205
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsExons 3-5 were replaced with a lacZ reporter. The deleted region encodes the two LIM domains and part of the homeodomain. Expression of the mutant allele was shown in the maxillary and mandibular processes of the first branchial arch, the pinna, and the medial ganglionic eminence of the telencephalon, corresponding to expression of the endogenous locus. (J:101205)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx8 Mutation:  14 strains or lines available
Original:  J:101205 Fragkouli A, et al., Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur J Neurosci. 2005 Jun;21(11):2923-38
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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