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Mapttm2Arbr
Targeted Allele Detail
Nomenclature
Symbol: Mapttm2Arbr
Name: microtubule-associated protein tau; targeted mutation 2, Silvia Arber
MGI ID: MGI:3590682
Synonyms: Tauf(mGFP), Tau-GFP-nlsLacZ, Tau-loxp-STOP-lox-mGFP-IRES-NLS-LacZ, TauloxP-stop-loxP-MARCKSeGFP-IRES-nlslacZ, Taulox-STOP-lox-FLP-INLA, TauLox-STOP-Lox-mGFP-IRESnlsLacZ, TauLSL-mEGFP, Tau:lxp-stp-lxp:mGFP-inLZ, Tau-mEGFP-LacZ, TaumGFP, TaumGFP-INLA, TaumGFP_nlacZ, TaumGFP-nlacZ, Tau-nLacZ, TauR
Gene: Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100886
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing loxP-STOP-loxP-mGFP-IRES-NLS-lacZ-pA was inserted into exon 2 of the locus. mGFP consists of the first 40 amino acids of the protein MARCKS, a plasmalemmal targeting sequence, fused to enhanced GFP (eGFP). (J:100886, J:154023)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  423 strains or lines available
References
Original:  J:100886 Hippenmeyer S, et al., A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
All:  116 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory