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Dkk2tm1Dwu
Targeted Allele Detail
Nomenclature
Symbol: Dkk2tm1Dwu
Name: dickkopf WNT signaling pathway inhibitor 2; targeted mutation 1, Dianqing Wu
MGI ID: MGI:3590649
Synonyms: Dkk2-
Gene: Dkk2  Location: Chr3:132085292-132180304 bp, + strand  Genetic Position: Chr3, 61.32 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100858
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced the four coding exons via homologous recombination. RT-PCR failed to detect transcript in mutant bone marrow stromal osteoblasts, and western blot confirmed absence of protein in mutants. (J:100858)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dkk2 Mutation:  9 strains or lines available
References
Original:  J:100858 Li X, et al., Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005 Sep;37(9):945-52
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory