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Bach1tm1Igar
Targeted Allele Detail
Nomenclature
Symbol: Bach1tm1Igar
Name: BTB and CNC homology 1, basic leucine zipper transcription factor 1; targeted mutation 1, Kazuhiko Igarashi
MGI ID: MGI:3590153
Synonyms: bach1-
Gene: Bach1  Location: Chr16:87698945-87733346 bp, + strand  Genetic Position: Chr16, 49.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100802
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced the entire second exon, encoding the initiation methionine and the BTB/POZ domain essential for protein function. Neither transcript nor protein was found in mutant mice In RT-PCR or immunoblot analysis, respectively. (J:100802)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bach1 Mutation:  40 strains or lines available
References
Original:  J:100802 Sun J, et al., Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J. 2002 Oct 1;21(19):5216-24
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory