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Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Transgene Detail
Nomenclature
Symbol: Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Name: transgene insertion N8, John F Elliott
MGI ID: MGI:3590083
Synonyms: DQ6 transgene, HLA-DQ6 transgene, Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell
Transgene: Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/ShiLtJ
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell expresses 3 genes
 
Mutation detailsThe human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A single founder line is maintained. (J:113267)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:113267 Hayward SL, et al., CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol. 2006 Jun 15;176(12):7715-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory