About   Help   FAQ
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Transgene Detail
Nomenclature
Symbol: Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Name: transgene insertion 1, John F Elliott
MGI ID: MGI:3590082
Synonyms: DQ8+, human CD4, DQ8 transgene, human CD4, DQA1*0301, DQB1*0302 transgene, Tg(CD2-CD4,HLA-DQA1*0301,HLA-DQB1*0302)1Ell, Tg(CD4,HLA-DQ8)1Ell
Transgene: Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/MrkTac
Transgene
description
Transgene Type:    Transgenic (random, expressed)
Mutation:    Insertion
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Although in NOD mice homozygous for this transgene alone endogeous NOD H2-Abetag7 and transgene-derived HLA-DQ8 are expressed at similar levels, virtually all CD4+ T-cell responses are H2Abeta1g7 restricted (J:87013).

Phenotypic Similarity to Human Syndrome: Idiopathic Dilated Cardiomyopathy in double homozygous mice of the strain NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell (J:86540)

References
Original:  J:87013 Liu J, et al., Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. Diabetes. 1999 Mar;48(3):469-77
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory