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Trp53tm1Thl
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1Thl
Name: transformation related protein 53; targeted mutation 1, Thomas Ludwig
MGI ID: MGI:3589921
Synonyms: p53flex7, Trp53loxP, Trp53tm1Ppp
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100683
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    A targeting construct was designed to insert loxP sites to flank exon 7. (J:100683)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  139 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Glioblastoma J:172585.

References
Original:  J:100683 Chen Z, et al., Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005 Aug 4;436(7051):725-30
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory