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Transgene Detail
Symbol: Tg(PRNP-APPSweInd)8Dwst
Name: transgene insertion 8, David Westaway
MGI ID: MGI:3589475
Synonyms: APP-KM670/671NL+V717F, CRND8, Tg19959, Tg(APPSwInd)8Dwst, TgCRND8, Tg(PRNP-APP*Swe*Ind)8Dwst
Transgene: Tg(PRNP-APPSweInd)8Dwst  Location: unknown  
Increase in creatine deposits in hippocampus of Tg(PRNP-APPSweInd)8Dwst/0 mice with age

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  (C3H/HeJ x C57BL/6J)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PRNP-APPSweInd)8Dwst expresses 1 gene
Mutation detailsThe transgene expresses the mutant human amyloid protein precursor APPSweInd, which bears both the Swedish (K670N/M671L) and the Indiana (V717F) mutations, under the control of the Syrian hamster prion protein promoter. Transgenic mice express the App protein in brain at approximately 5 times the level of control mice. High level production of the pathogenic Abeta42 form of the Abeta peptide is seen by three months of age. (J:69967)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:69967 Chishti MA, et al., Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001 Jun 15;276(24):21562-70
All:  138 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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