Gpx1^tm2Mgr
Targeted Allele Detail

Summary

• Symbol: Gpx1^tm2Mgr
• Name: glutathione peroxidase 1; targeted mutation 2, Grant R MacGregor
• MGI ID: MGI:3589262
• Synonyms: Gpx1^-
• Gene: Gpx1 Location: Chr9:108216279-108217541 bp, + strand Genetic Position: Chr9, 59.24 cM, cytoband F1
• Alliance: Gpx1^tm2Mgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62395
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A beta-geo cassette was inserted in-frame into exon 1 to create a fusion transcript consisiting of the first third of the Gpx1 coding region and beta-geo. X-gal staining of E13.5 embryos detected expression in the liver, spinal cord, eye and brain stem, and staining of adults demonstrated expression in liver and kidney cortex. (J:62395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx1 Mutation: 24 strains or lines available

References

• Original: J:62395 Esposito LA, et al., Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic Biol Med. 2000 Mar 1;28(5):754-66
• All: 1 reference(s)