About   Help   FAQ
Targeted Allele Detail
Symbol: Dicer1tm1Bdh
Name: dicer 1, ribonuclease type III; targeted mutation 1, Brian D Harfe
MGI ID: MGI:3589208
Synonyms: Dcrflox, Dcrfx, Dicer1fl, dicerfl, Dicerflox, Dicerlox
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Germline Transmission:  Earliest citation of germline transmission: J:100475
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert loxP sites around the exon that encodes most of the second RNaseIII domain as well as an frt-flanked neo within the loxP-encompassed sequence. Cre-mediated removal of the sequence would result in the loss of 90 amino acids, a loss that does not create a downstream frame-shift or an unstable protein. (J:100475)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 253 assay results
In Structures Affected by this Mutation: 48 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  62 strains or lines available
Original:  J:100475 Harfe BD, et al., The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10898-903
All:  200 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory