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Targeted Allele Detail
Symbol: Rhoctm1Mak
Name: ras homolog family member C; targeted mutation 1, Tak W Mak
MGI ID: MGI:3589206
Synonyms: RhoC-, RhoCdelta2-3
Gene: Rhoc  Location: Chr3:104788375-104794459 bp, + strand  Genetic Position: Chr3, 45.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:100482
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCre-mediated deletion of exons 2 and 3 caused termination codons in all three reading frames and removed 70% of the protein sequence. Northern blot of mutant MEFs confirmed the creation of a null allele. (J:100482)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rhoc Mutation:  16 strains or lines available
Original:  J:100482 Hakem A, et al., RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev. 2005 Sep 1;19(17):1974-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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