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QTL Variant Detail
QTL variant: Cd4ts6C3H
Name: CD4 T cell subset 6; C3H
MGI ID: MGI:3589134
QTL: Cd4ts6  Location: Chr13:17168545-17168684 bp  Genetic Position: Chr13, cM position of peak correlated region/allele: 5.92 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3H
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with P-glycoprotein positive CD4 T cell subsetlevels, Pcd4ts2, mapped to 30 cM (D13Mit64) on mouse Chromosome 13 and a QTL associated with CD4 T cell subset levels, Cd4ts6, mapped to 9 cM (D13Mit57) on mouse Chromosome 13 with statistical significance of P<0.05. Pcd4ts2 is associated with P-glycoprotein positive CD4 T cell levels in 8 month old mated mice. Cd4ts6 is associated with CD4 T cell levels in 18 month old virgin mice.

Original:  J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
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