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QTL Variant Detail
QTL variant: Cd4ts4C3H
Name: CD4 T cell subset 4; C3H
MGI ID: MGI:3589128
QTL: Cd4ts4  Location: Chr9:65831056-65831177 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 35.6 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C3H
Allele Type:    QTL
Mutation:    Undefined
Mutation detailsThis allele confers increased proportion of CD4 T cells in 8 month old virgin mice compared to DBA/2. (J:83220)
View phenotypes and curated references for all genotypes (concatenated display).

Mapping and Phenotype information for this QTL, its variants and associated markers


Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with CD4 T cell subset levels, Cd4ts4, mapped to 35 cM (D9Mit104) on mouse Chromosome 9 with statistical significance of P<0.05. Cd4ts4 is associated with CD4 T cell levels in 8 month old virgin mice.

Original:  J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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