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Mus81tm1Chmg
Targeted Allele Detail
Nomenclature
Symbol: Mus81tm1Chmg
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Clare H McGowan
MGI ID: MGI:3588581
Synonyms: Mus81-
Gene: Mus81  Location: Chr19:5482345-5488402 bp, - strand  Genetic Position: Chr19, 4.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100407
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Cre mediated excision was used to remove exons 9-12, which includes the endonuclease domain. (J:100407)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mus81 Mutation:  20 strains or lines available
References
Original:  J:100407 Dendouga N, et al., Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol. 2005 Sep;25(17):7569-79
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory