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Sit1tm1Lsmn
Targeted Allele Detail
Nomenclature
Symbol: Sit1tm1Lsmn
Name: suppression inducing transmembrane adaptor 1; targeted mutation 1, Luca Simeoni
MGI ID: MGI:3588572
Synonyms: SIT-
Gene: Sit1  Location: Chr4:43482083-43483709 bp, - strand  Genetic Position: Chr4, 23.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100408
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding sequence was replaced with a neomycin resistance cassette. Western blot confirmed successful targeting in mutants and ablation of translation. (J:100408)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sit1 Mutation:  11 strains or lines available
References
Original:  J:100408 Simeoni L, et al., The transmembrane adapter protein SIT regulates thymic development and peripheral T-cell functions. Mol Cell Biol. 2005 Sep;25(17):7557-68
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/03/2022
MGI 6.19
The Jackson Laboratory