Gata1^tm9Sho
Targeted Allele Detail

Summary

• Symbol: Gata1^tm9Sho
• Name: GATA binding protein 1; targeted mutation 9, Stuart H Orkin
• MGI ID: MGI:3588564
• Synonyms: Gata-1S³¹⁰/A, Gata1^S310A
• Gene: Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
• Alliance: Gata1^tm9Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100411
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neo cassette was inserted downstream of exon 4 and exon 6 was replaced with an exon 6 containing a nucleotide substitution that resulted in an amino acid substitution of alanine for serine at residue 310 (S310A). The neo cassette was removed by germ-line, cre-mediated recombination. (J:132560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata1 Mutation: 44 strains or lines available

References

• Original: J:100411 Kadri Z, et al., Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol. 2005 Sep;25(17):7412-22
• All: 3 reference(s)