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Myo1atm1Mtys
Targeted Allele Detail
Nomenclature
Symbol: Myo1atm1Mtys
Name: myosin IA; targeted mutation 1, Matthew J Tyska
MGI ID: MGI:3587749
Gene: Myo1a  Location: Chr10:127705170-127720887 bp, + strand  Genetic Position: Chr10, 74.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100193
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1/SvImJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo/ura3 cassette replaced the first three exons. Absence of protein in mutants was confirmed by immunoblot of small intestines. Immunostaining of mutant duodenal sections with an antibody directed against the TH1 domain showed the expected lack of signal in mutants. (J:100193)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myo1a Mutation:  31 strains or lines available
References
Original:  J:100193 Tyska MJ, et al., Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell. 2005 May;16(5):2443-57
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory