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Cux1tm1Rhsc
Targeted Allele Detail
Nomenclature
Symbol: Cux1tm1Rhsc
Name: cut-like homeobox 1; targeted mutation 1, Richard H Scheuermann
MGI ID: MGI:3586992
Synonyms: cux/CDPdeltaHD
Gene: Cux1  Location: Chr5:136248135-136567490 bp, - strand  Genetic Position: Chr5, 75.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100055
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace the sequence encoding the homeodomain in exons 20 and 21 with a neomycin resistance gene. Immunoblot of mutant thymic nuclear extracts confirmed absence of wild-type protein and presence of a smaller protein equivalent to the predicted size of the mutant protein containing only 4 amino acids of the homeodomain and a deletion of the C-terminal repression domain. This band was present at a reduced intensity compared to the wild-type band in controls, suggesting the remaining protein has partial function and is a hypomorph. (J:100055)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cux1 Mutation:  66 strains or lines available
References
Original:  J:100055 Sinclair AM, et al., Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice. Blood. 2001 Dec 15;98(13):3658-67
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory