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Aff4tm1Nosa
Targeted Allele Detail
Nomenclature
Symbol: Aff4tm1Nosa
Name: AF4/FMR2 family, member 4; targeted mutation 1, Tetsuya Nosaka
MGI ID: MGI:3586991
Synonyms: AF5q31-
Gene: Aff4  Location: Chr11:53350833-53421830 bp, + strand  Genetic Position: Chr11, 31.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100030
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 2 and 3, encoding the initation codon as well as the N-terminal homology domain and the partial transactivation domain. RT-PCR of mutant MEFs failed to detect transcript. (J:100030)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 39 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aff4 Mutation:  62 strains or lines available
References
Original:  J:100030 Urano A, et al., Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol. 2005 Aug;25(15):6834-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory