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Ndntm1Ky
Targeted Allele Detail
Nomenclature
Symbol: Ndntm1Ky
Name: necdin; targeted mutation 1, Kazuaki Yoshikawa
MGI ID: MGI:3586988
Synonyms: Ndn-
Gene: Ndn  Location: Chr7:62346569-62350262 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:100024
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insetion of a PGK-neo into the coding sequence disrupted the locus. Western blot of mutants showed absence of protein. (J:100024)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:  12 strains or lines available
References
Original:  J:100024 Kuwako K, et al., Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005 Jul 27;25(30):7090-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory