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Transgene Detail
Symbol: Tg(HLA-DQA1,HLA-DQB1)1Dv
Name: transgene insertion 1, Chella David
MGI ID: MGI:3586633
Synonyms: Abeta0.DQ8, DQ8, HLA-DQ8, HLA-DQ8 Tg, HLA-DQA1*0301/DQB1*0302, Tg(HLA-DQA1*301,HLA-DQB1*302)1Dv
Transgene: Tg(HLA-DQA1,HLA-DQB1)1Dv  Location: unknown  
Strain of Origin:  (CBA/J x B10.M-H2f)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA 30-kb human genomic DNA fragment containing the entire HLA-DQA1*0301 gene and a promoter-truncated HLA-DQB1*0302 gene from cosmid H11A and a 38-kb DNA fragment containing the entire HLA-DQB1*0302 gene from cosmid X10A were coinjected. (J:88296)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Flow cytometric analysis of peripheral blood leukocytes (PBL) using a monoclonal antibody to HLA-DQ demonstrated that transgenic mice express the transgenes. 25-40% of the PBLs of mixed-background transgenic mice homozygous for the targeted MHC class II mutation H2-Ab1tm1Dim express the transgenes. Lymph nodes of such mice contain three-fold the levels of CD4+ CD44+ T-cells as do those of nontransgenic MHC class II-deficient mice, levels similar to those of class II-sufficient mice. Immunization of transgenic H2-Ab1tm1Dim homozygous mice with bovine collagen II results in a strong IgG antibody response to the immunogen, and 66% of these mice develop severe, persistent arthritis. (J:88296)
Original:  J:88296 Nabozny GH, et al., HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med. 1996 Jan 1;183(1):27-37
All:  61 reference(s)

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