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Upp1tm1Gp
Targeted Allele Detail
Nomenclature
Symbol: Upp1tm1Gp
Name: uridine phosphorylase 1; targeted mutation 1, Giuseppe Pizzorno
MGI ID: MGI:3586525
Synonyms: UPase-
Gene: Upp1  Location: Chr11:9118103-9136170 bp, + strand  Genetic Position: Chr11, 6.13 cM, cytoband A1-2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:99912
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 3, all of exon 4 and most of exon 5 were replaced with a neomycin resistance gene. This deletion resulted in the loss of 92 amino acids followed by a frame shift. RT-PCR of mutant liver, gut, lung and kidney confirmed absence of transcript. (J:100071)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Upp1 Mutation:  41 strains or lines available
References
Original:  J:99912 Cao D, et al., Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J Biol Chem. 2005 Jun 3;280(22):21169-75
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory