Del(2Dlx1-Dlx2)1Jlr
Targeted Allele Detail

Summary

• Symbol: Del(2Dlx1-Dlx2)1Jlr
• Name: deletion, Chr 2, John L R Rubenstein 1
• MGI ID: MGI:3586512
• Synonyms: D1x-1&2-D15.6/neo, Dlx1/2-, Dlx1&2-null, Dlx1/Dlx2^tm2Jlr
• Gene: Del(2Dlx1-Dlx2)1Jlr Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40427
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(2Dlx1-Dlx2)1Jlr involves 7 genes/genome features (Rr294, Rr293, Dlx1 ...) View all
• Mutation details: A 15.6 kb deletion removes all of exons 2 and 3 of both Dlx1 and Dlx2 and the entire intergenic region and replaces it with a neomycin resistance gene. (J:40427)

Expression

In Mice Carrying this Mutation:	660 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(2Dlx1-Dlx2)1Jlr Mutation: 1 strain or line available

References

• Original: J:40427 Qiu M, et al., Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15;185(2):165-84
• All: 36 reference(s)