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Targeted Allele Detail
Symbol: Del(2Dlx1-Dlx2)1Jlr
Name: deletion, Chr 2, John L R Rubenstein 1
MGI ID: MGI:3586512
Synonyms: D1x-1&2-D15.6/neo, Dlx1/2-, Dlx1&2-null, Dlx1/Dlx2tm2Jlr
Gene: Del(2Dlx1-Dlx2)1Jlr  Location: unknown  Genetic Position: Chr2, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:40427
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(2Dlx1-Dlx2)1Jlr involves 3 genes/genome features (Dlx1, Dlx1as, Dlx2) View all
Mutation detailsA 15.6 kb deletion removes all of exons 2 and 3 of both Dlx1 and Dlx2 and the entire intergenic region and replaces it with a neomycin resistance gene. (J:40427)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 102 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(2Dlx1-Dlx2)1Jlr Mutation:  1 strain or line available
Original:  J:40427 Qiu M, et al., Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15;185(2):165-84
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory