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Targeted Allele Detail
Symbol: Chrngtm1Mtak
Name: cholinergic receptor, nicotinic, gamma polypeptide; targeted mutation 1, Masazumi Takahashi
MGI ID: MGI:3586495
Synonyms: AChRgamma-
Gene: Chrng  Location: Chr1:87133533-87139557 bp, + strand  Genetic Position: Chr1, 44.07 cM
Alliance: Chrngtm1Mtak page
Germline Transmission:  Earliest citation of germline transmission: J:99894
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo was inserted to replace exon 4. Northern blot of mutants failed to detect the wild-type transcript. However, shorter transcripts thought to result from alternative splicing were present. (J:99894)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Chrng Mutation:  20 strains or lines available
Original:  J:99894 Takahashi M, et al., Spontaneous muscle action potentials fail to develop without fetal-type acetylcholine receptors. EMBO Rep. 2002 Jul;3(7):674-81
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory