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H2-Ab1bm12
Spontaneous Allele Detail
Nomenclature
Symbol: H2-Ab1bm12
Name: histocompatibility 2, class II antigen A, beta 1; b haplotype mutation 12
MGI ID: MGI:3586447
Synonyms: bm12, H-2bm, H2bm12
Gene: H2-Ab1  Location: Chr17:34482201-34488392 bp, + strand  Genetic Position: Chr17, 17.98 cM
Mutation
origin
Strain of Origin:  (C57BL/6 x BALB/c)F1
Mutation
description
Allele Type:    Spontaneous
Mutation:    Nucleotide substitutions
 
Mutation detailsThree non-consecutive nucleotide changes occurred, resulting in three amino acid substitutions in the beta1 exon. The amino acid changes consist of codon 67 (isoleucine to phenylalanine), codon 70 (arginine to glutamine) and codon 71 (threonine to lysine). These changes were likely the product of gene conversion of H2-Ab1b with sequence from H2-Ebb. (J:99766, J:99767, J:100015, J:109266)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:  70 strains or lines available
Notes
Genbank ID for this allele: M54876
References
Original:  J:99770 McKenzie IF, et al., B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse. J Exp Med. 1979 Dec 1;150(6):1323-38
All:  140 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory