Rdh11^tm1Akjc
Targeted Allele Detail

Summary

• Symbol: Rdh11^tm1Akjc
• Name: retinol dehydrogenase 11; targeted mutation 1, Anne Kasus-Jacobi
• MGI ID: MGI:3586379
• Synonyms: rdh11^-
• Gene: Rdh11 Location: Chr12:79221007-79238629 bp, - strand Genetic Position: Chr12, 35.51 cM
• Alliance: Rdh11^tm1Akjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Velicigene technology was used to insert a lacZ-PGK-neo cassette in frame with the first four amino acids. Immunoblot of liver and testis showed absence of protein in mutants. (J:99913)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdh11 Mutation: 16 strains or lines available

References

• Original: J:99913 Kasus-Jacobi A, et al., Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo. J Biol Chem. 2005 May 27;280(21):20413-20
• All: 4 reference(s)